Urocortin II, human

Urocortin II, human is a synthetic research peptide in the urocortin / CRF-family peptide family. Urocortins are members of the corticotropin-releasing factor peptide family. Urocortin 1 can activate both CRF1 and CRF2 receptors, whereas urocortin 2 and urocortin 3 show greater CRF2 selectivity. Comparative sequence and structural studies have identified peptide regions that contribute to receptor subtype recognition and activation.

• CRF1/CRF2 receptor binding and signaling assays
• receptor-subtype selectivity studies
• stress-axis peptide research
• structure-activity analysis of CRF-family peptides
• analytical peptide controls

For fragments, substituted analogs, labeled peptides, stereochemical variants, or terminally modified forms, experimental behavior should be evaluated for the exact construct rather than assumed to match the native parent peptide. Sequence-dependent solubility, aggregation, adsorption, oxidation, and stability should be considered when establishing reconstitution, storage, and assay conditions.

1. Three-amino acid motifs of urocortin II and III determine receptor selectivity
2. Structural basis for hormone recognition by the corticotropin-releasing factor receptors