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Stearyl-R8 (Stearylated Octaarginine) is based on an arginine-rich R8 (octaarginine) cell-penetrating peptide. Oligoarginine peptides are widely used as compact CPPs because the guanidinium groups of arginine interact efficiently with anionic cellular surfaces and can promote uptake of attached research cargos.
Stearylated Octaarginine
In stearyl-R8, a hydrophobic C18 stearyl group is attached to the arginine-rich peptide. Published studies showed that N-terminal stearylation can enhance the membrane association and transfection properties of arginine-rich peptide systems. The combination of a hydrophobic lipid tail and highly cationic peptide produces an amphiphilic delivery module.
Research Applications
- Cell-penetrating peptide studies
- Lipid/peptide delivery systems
- Membrane interaction assays
- Nanoparticle surface modification
- Oligonucleotide or macromolecule delivery research
References
Futaki S, et al. Stearylated arginine-rich peptides: a new class of transfection systems. Bioconjug Chem. 2001.
doi: 10.1021/bc015508l.
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Research Use Only. Not for human, diagnostic, clinical, or therapeutic use.
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