Somatostatin-25

Somatostatin 25 isolated from bovine hypothalamus shows somatostatin-like immunoactivity and bioactivity in vitro. It appears to be more potent than somatostatin based on an in vitro bioassay. somatostatin inhibits the secretion of somatotropin.

Somatostatin-25 is a synthetic research peptide in the somatostatin family. The listed sequence/design is Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys(Disulfide bridge: Cys14-Cys25). Somatostatin peptides and analogs are research ligands for SSTR1-SSTR5. Sequence modification and cyclization have been used extensively to define receptor subtype selectivity and binding.

• receptor or binding assays
• competition experiments
• enzymatic-processing studies
• antibody or antigen controls
• analytical method development
• LC-MS/HPLC reference work
• comparative structure-activity experiments

Because this product may be a fragment, substituted analog, stereochemical variant, or terminally modified form, its activity should not be assumed to be identical to the native parent peptide. Peptide solubility, aggregation, adsorption to surfaces, and stability can vary with sequence, concentration, pH, ionic strength, and terminal modifications, so assay-specific reconstitution and storage conditions should be validated experimentally.

1. Cloned somatostatin receptors and subtype-selective peptides (PMID 8100350).
2. Characterization of somatostatin receptor subtypes using peptide analogues (PMID 7535424).