Product Name | [Ser140]-Myelin Proteolipid Protein (139-151) (depalmitoylated), |
Product Quantity | 5mg |
Catalog Number | LT0711 |
Molecular Weight | 1521.7 |
Formula | C72H104N20O17 |
Sequence | His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe |
Product Description | The PLP (Myelin Proteolipid Protein) (139-151) Peptide has been found to be highly immunogenic in inducing Experimental Allergic Encephalomyelitis (EAE) in SJC/J (H-2s) mice as part of an autoimmune response. The sequence is derived from PLP, with PLP cysteine replaced by serine. This fragment of myelin proteolipid protein is an encephalitogenic determinant, able to bind to diverse sets of T cell receptors. |
Scientific Background | [Ser140]-Myelin Proteolipid Protein (139-151) (depalmitoylated), is a 13-residue synthetic peptide with the sequence His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe. palmitoylation introduces a hydrophobic lipid group. These sequence-derived properties describe the reagent chemically; no specific receptor, enzyme, pathway, disease association, or biological activity is assigned without product-specific experimental evidence. |
Research Applications | - LC-MS/HPLC analytical method development
- sequence-specific assay controls
|
Experimental Notes | Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions. |
