RGD-4C

RGD-4C is a synthetic RGD integrin-binding peptide. This product contains the Arg-Gly-Asp (RGD) cell-adhesion motif. RGD is a canonical integrin-recognition sequence in extracellular-matrix proteins such as fibronectin. Linear, cyclic, flanked, and chemically modified RGD peptides are widely used to study integrin binding and cell adhesion.

• integrin binding and competition assays
• cell-adhesion studies
• biomaterial functionalization research
• linear-versus-cyclic RGD comparisons

The behavior of a motif embedded in a longer peptide can differ from the isolated tag or parent sequence. Flanking residues, linkers, phosphorylation, fluorophores, affinity handles, cyclization, and terminal modifications may alter accessibility, binding, uptake, or assay performance.

1. Arg-Gly-Asp (RGD): a cell adhesion motif
2. RGD and YIGSR synthetic peptides facilitate cellular adhesion