Peptide YY, Human

Peptide YY (PYY) is a 36-amino acid regulatory gut hormone present in endocrine cells in the intestine. This peptide acts both as an endocrine and a paracrine agent.

Peptide YY, Human is a synthetic research peptide in the peptide YY family. The listed sequence/design is Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2. Peptide YY is a 36-residue member of the NPY peptide family. PYY(1-36), PYY(3-36), and analogs are useful for studying Y-receptor subtype binding and sequence determinants of receptor selectivity.

• receptor or binding assays
• competition experiments
• enzymatic-processing studies
• antibody or antigen controls
• analytical method development
• LC-MS/HPLC reference work
• comparative structure-activity experiments

Because this product may be a fragment, substituted analog, stereochemical variant, or terminally modified form, its activity should not be assumed to be identical to the native parent peptide. Peptide solubility, aggregation, adsorption to surfaces, and stability can vary with sequence, concentration, pH, ionic strength, and terminal modifications, so assay-specific reconstitution and storage conditions should be validated experimentally.

1. Structure and receptor binding of PYY analogs (PMID 11825645).
2. Characterization of PYY(1-36) and PYY(3-36) (PMID 7984499).