| Our Phosphorylated PARP1 Y158 Peptide, with the sequence C-EKPQLGMIDRW-pY-HPG-S-FVKNREE, is a highly specialized research tool designed for advanced studies in cancer biology and therapeutic development. This peptide is a crucial component in understanding the role of PARP1 phosphorylation in DNA repair mechanisms and the development of resistance to PARP inhibitors in cancer treatment.
Key Features:
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Specific Phosphorylation Site: The peptide includes a phosphorylation at the Y158 amino acid, a critical site for the study of PARP1's role in DNA damage response and repair.
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Relevance in Cancer Research: Y158 phosphorylation of PARP1 by FGFR3 has been shown to contribute to the resolution of PARP trapping in tumor cells, a key mechanism in cancer progression and treatment resistance.
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Utility in Drug Resistance Studies: The peptide aids in understanding how FGFR-mediated phosphorylation of PARP1 affects the efficacy of PARP inhibitors, providing insights into overcoming drug resistance.
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Biomarker Potential: Phosphorylated Y158 PARP1 serves as a potential biomarker for stratifying patients for combination treatments with FGFR inhibitors and PARP inhibitors.
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Structural Insights: The location of Y158 near the PARP1 ZF2 domain and DNA interacting residues suggests its involvement in protein structure stabilization and PARP1-DNA interaction dynamics.
Applications:
- Targeted Cancer Therapy Research: Essential for developing combination therapies using FGFR inhibitors and PARP inhibitors.
- Molecular Biology Studies: Useful in exploring the structural and functional aspects of PARP1 in DNA repair.
- Biomarker Development: Aids in identifying patients who would benefit from specific cancer treatments based on PARP1 phosphorylation status.
Quality Assurance:
Our Phosphorylated PARP1 Y158 Peptide is synthesized with precision, ensuring high purity and consistency. Each batch undergoes rigorous quality control and is accompanied by a comprehensive Certificate of Analysis.
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