Scientific Background | OVA 247–264 is a 18-residue synthetic peptide with the sequence Asp-Glu-Val-Ser-Gly-Leu-Glu-Gln-Leu-Glu-Ser-Ile-Ile-Asn-Phe-Glu-Lys-Leu. C-terminal amidation removes the terminal carboxylate charge. The sequence contains 1 Asp and 4 Glu residues, contributing anionic character near neutral pH. These sequence-derived properties describe the reagent chemically; no specific receptor, enzyme, pathway, disease association, or biological activity is assigned without product-specific experimental evidence. |
Experimental Notes | Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions. |
Reference | 1. Aurora A controls CD8+ T cell cytotoxic activity and antiviral response; Scientific Reports volume 9, Article number: 2211 (2019);
https://www.nature.com/articles/s41598-019-38647-y
...Ovoalbumin peptide (SIINFEKL) was synthesized by LifeTein... 2. Jeon D, Hill E, Moseman JE, McNeel DG. Combining toll-like receptor agonists with immune checkpoint blockade affects antitumor vaccine efficacy. J Immunother Cancer. 2024 May 3;12(5):e008799. doi: 10.1136/jitc-2024-008799. PMID: 38702146; PMCID: PMC11086196.
...Ovalbumin peptides for H-2b-restricted class I epitope (SIINFEKL) and class II epitope (ISQAVHAAHAEINEAGR, OVA-II) were synthesized, and the purity and identity were confirmed by mass spectrometry and gas chromatography (LifeTein, Hillsborough, New Jersey, USA).... |
