Orn8, Urotensin II, human

Urotensin II is a cyclic 11-amino acid peptide with sequence similarity to somatostatin-14. Urotensin II is a highly potent vasoconstrictor that has been identified as a ligand for the orphan receptor GPR14 which elicits potent vasoconstriction in primates. Intracerebroventricular urotensin II administration produces pressor and tachycardic responses. Urotensin II is localized to the medulla oblongata of the brain and the spinal cord in the central nervous system, but is also found in adrenal glands, kidney and spleen, suggesting neurohormonal or hormonal properties

Orn8, Urotensin II, human is a 10-residue synthetic peptide with the sequence Glu-Thr-Pro-Asp-Cys-Phe-Trp-Tyr-Cys-Val. The sequence contains 2 cysteine residues, providing potential thiol/disulfide chemistry when the thiol is available; contains 3 aromatic residues that can contribute to hydrophobic or aromatic interactions. These sequence-derived properties describe the reagent chemically; no specific receptor, enzyme, pathway, disease association, or biological activity is assigned without product-specific experimental evidence.

• thiol-selective conjugation or immobilization studies
• LC-MS/HPLC analytical method development
• sequence-specific assay controls

Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions.