Mouse TLR3 Protein (LTP10518)

Product Name
Mouse TLR3 Protein (LTP10518)
Catalog Number
LTP10518
Quantity
100ug
Price
$473 In stock
Background
TLR3 is expressed in the central nervous system (CNS), where it is required to control HSV-1, which spreads from the epithelium to the CNS via cranial nerves. TLR3 is also expressed in epithelial and dendritic cells, which apparently use TLR3-independent pathways to prevent further dissemination of HSV-1 and to provide resistance to other pathogens in TLR3-deficient patients. Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance of TLR3.
Description
Recombinant Mouse TLR3 Protein is expressed from Expi293 with His tag at the C-terminal. It contains Thr25-Leu705.
Target
TLR3
Species
Mouse
Gene/Protein ID
Q99MB1
Exact Sequence
Thr25-Leu705
Molecular Weight
The protein has a predicted MW of 78.6 kDa. Due to glycosylation, the protein migrates to 85-110 kDa based on the Tris-Bis PAGE result.
Activity
0
Tag
C-His
Express System
Expi293
Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 8.0). Normally 8% trehalose is added as a protectant before lyophilization.
Stability and Storage

Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Shipping
Shipped at ambient temperature.
Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.

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Mouse TLR3 Protein (LTP10518)
  • 5 Units in Stock
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