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| Mouse IL-7R alpha/CD127 Protein (LTP10174) |
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| LTP10174 |
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| 100ug |
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$406 In stock |
| Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7R? and ?c) are essential for normal lymphoid development. IL-7 and IL-7R activate three main pathways: STAT5, PI3K/Akt/mTOR and MEK/Erk, ultimately leading to the promotion of leukemia cell viability, cell cycle progression and growth. |
| Recombinant Mouse IL-7R alpha/CD127 Protein is expressed from Expi293 with hFc tag at the C-terminal. It contains Glu21-Asp239. |
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| IL-7R alpha/CD127 |
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| Mouse |
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| NP_032398.3 |
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| Glu21-Asp239 |
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| The protein has a predicted MW of 51.74 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on the Tris-Bis PAGE result. |
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| Immobilized Human IL-7, No Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Mouse IL-7R alpha, hFc Tag with the EC50 of 10.2ng/ml determined by ELISA. See testing image for detail. |
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| C-hFc |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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