Men 10376

Men 10376 is a potent antagonist with high affinity and selectivity for the NK-2 receptor in vitro and in vivo.

Men 10376 is a 7-residue synthetic peptide with the sequence Asp-Tyr-Trp-Val-Trp-Trp-Lys. C-terminal amidation removes the terminal carboxylate charge. The sequence contains 4 aromatic residues that can contribute to hydrophobic or aromatic interactions; has a relatively high hydrophobic-residue fraction that can influence aqueous solubility and surface adsorption. These sequence-derived properties describe the reagent chemically; no specific receptor, enzyme, pathway, disease association, or biological activity is assigned without product-specific experimental evidence.

• LC-MS/HPLC analytical method development
• sequence-specific assay controls

Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions.