Magainin Spacer Peptide

Magainin Spacer Peptide is a synthetic research peptide in the magainin antimicrobial peptide family. Magainins are cationic amphipathic antimicrobial peptides originally characterized from amphibian skin. Magainin-2 and related analogs interact with lipid membranes, and peptide helicity, charge, hydrophobicity, and membrane composition influence permeabilization and antimicrobial activity.

• antimicrobial activity assays
• membrane permeabilization studies
• liposome leakage experiments
• AMP structure-activity comparisons

The exact sequence, isoform, residue substitutions, amidation, stereochemistry, labels, and other chemical modifications can change activity substantially. For receptor-activating peptides and membrane-active peptides, concentration and assay format are especially important and should be matched to the intended experimental system.

1. Thermodynamics of the coil-alpha-helix transition of magainin-2 analogs
2. Antitumor activity of the antimicrobial peptide magainin II