Lys-(Tyr8)-Bradykinin

Lys-(Tyr8)-Bradykinin is a synthetic research peptide in the bradykinin/kinin family. The listed sequence/design is Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Tyr-Arg. Bradykinin and related kinins are peptide ligands used to investigate kinin B1 and B2 receptors. Defined analogs and truncations support receptor-binding and structure-activity studies.

• receptor or binding assays
• competition experiments
• enzymatic-processing studies
• antibody or antigen controls
• analytical method development
• LC-MS/HPLC reference work
• comparative structure-activity experiments

Because this product may be a fragment, substituted analog, stereochemical variant, or terminally modified form, its activity should not be assumed to be identical to the native parent peptide. Peptide solubility, aggregation, adsorption to surfaces, and stability can vary with sequence, concentration, pH, ionic strength, and terminal modifications, so assay-specific reconstitution and storage conditions should be validated experimentally.

1. Structure-activity studies of bradykinin and related peptides (PMID 1846119).
2. Structural modification of bradykinin-related peptides and receptor selectivity (PMID 18182242).