Product Name | Luteinizing Hormone Releasing Hormone LH-RH |
Product Quantity | 5mg |
Catalog Number | LT1766 |
Molecular Weight | 1182.4 |
Formula | C55H75N17O13 |
Sequence | Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 |
Product Description | This decapeptide is a hypothalamic hormone that controls the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the pituitary gland and promotes mating behavior. It stimulates the secretion of gonadotropins after its interaction with specific G-protein-coupled receptors that are present in plasma membranes of pituitary gonadotrophs. In addition to hypophysiotropic effect, it also plays a autocrine/paracrine role in peripheral organs such as prostate, breast and ovary. |
Scientific Background | Luteinizing Hormone Releasing Hormone LH-RH is a synthetic research peptide in the gonadotropin-releasing hormone (GnRH/LH-RH) peptide family. GnRH is a hypothalamic decapeptide acting through the GnRH receptor. Synthetic GnRH analogs such as leuprolide incorporate substitutions and terminal modifications that increase stability or modify receptor pharmacology. Native LH-RH, species variants, and analogs are useful for receptor, structure-activity, and analytical studies. |
Research Applications | - GnRH receptor assays
- GnRH analog structure-activity studies
- species-variant comparisons
- analytical peptide reference work
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Experimental Notes | The exact sequence, residue range, stereochemistry, cyclization, terminal state, species, and chemical modifications can materially affect activity. The supplied construct should be matched to the intended assay and the specific literature context. |
Selected References | - Development and pharmacology of GnRH analogs including leuprolide
- Cyclic and stabilized GnRH analog structure-activity studies
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