Leu-Enkephalin, amide

Leu-Enkephalin, amide is a synthetic research peptide in the enkephalin/opioid family. The listed sequence/design is Tyr-Gly-Gly-Phe-Leu-NH2. Enkephalins are endogenous opioid peptides used to examine mu- and delta-opioid-receptor recognition. Sequence substitutions and terminal modifications are commonly used to probe receptor selectivity and metabolic stability.

• receptor or binding assays
• competition experiments
• enzymatic-processing studies
• antibody or antigen controls
• analytical method development
• LC-MS/HPLC reference work
• comparative structure-activity experiments

Because this product may be a fragment, substituted analog, stereochemical variant, or terminally modified form, its activity should not be assumed to be identical to the native parent peptide. Peptide solubility, aggregation, adsorption to surfaces, and stability can vary with sequence, concentration, pH, ionic strength, and terminal modifications, so assay-specific reconstitution and storage conditions should be validated experimentally.

1. Structural parameters for mu/delta opioid receptor recognition by modified enkephalins (PMID 2828622).
2. Mu versus delta opioid receptor involvement in enkephalin-induced analgesia (PMID 6086366).