Indolicidin

Indolicidin is a synthetic research peptide in the indolicidin antimicrobial peptide family. Indolicidin is a tryptophan-rich cationic tridecapeptide amide originally isolated from bovine neutrophils. It exhibits broad antimicrobial activity and interacts with microbial membranes; analog studies show that sequence and aromatic-residue organization influence membrane leakage and antimicrobial potency.

• antimicrobial susceptibility assays
• membrane perturbation studies
• indolicidin analog comparisons
• cationic peptide structure-function studies

The exact sequence, isoform, residue substitutions, amidation, stereochemistry, labels, and other chemical modifications can change activity substantially. For receptor-activating peptides and membrane-active peptides, concentration and assay format are especially important and should be matched to the intended experimental system.

1. Indolicidin, a novel bactericidal tridecapeptide amide from bovine neutrophils
2. Indolicidin-derived antimicrobial peptide analog structure-activity study