Catalog Number: |
LT110006 |
Name: |
amlintide, Amylin (1 - 37), human, amylin, Pancreatic Amylin, Islet Amyloid, islet amyloid polypeptide precursor, IAPP precursor |
CAS Number: |
122384-88-7 |
Lot Number: | |
Sequence: |
KCNTATCATQ RLANFLVHSS NNFGAILSST NVGSNTY,(C-terminal amide: Tyr37; Disulfide bridge:2-7),
KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY,
H-KC(1)NTATC(1)ATQRLANFLVHSSNNFGAILSSTNVGSNTY-[NH2].
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KCNTATCVTQRLANFLLRSSNNLGAILSPT;
KCNTATCVTQRLADFLVRSSSNIGAIYS;
KCNTATCVTQRLADFLLRSSNNLGAILSPTNVGSNTY;
KCNTATCVTQRLANFLLRSSNNLGAIYSPTNVGSNTY;
KCNTATCVTQRLANFLVRSSNNLGAILSPTNVGSNTY;
KCNTATCVTQRLADFLLRSSSNIGAIYSPTNVGSNTY;
KCNTATCVTQRLADFLVRSSSNIGAILSPTNVGSNTY;
KCNTATCVTQRLADFLVRSSSNLGAIYSPTNVGSNTY;
KCNTATCVTQRLANFLLRSSNNIGAILSPTNVGSNTY;
KCNTATCATQRLANFLLRSSNNLGAILSPTNVGSNTY;
KCNTATCATQRLADFLVRSSSNIGAIYSPTNVGSNTY;
|
Quantity: |
1mg, acetate salt, Lyophilized |
Purity: |
98.026% HPLC, acetate salt |
Molecular Formula: |
C165H265N51O55S2 |
Molecular Weight: | |
Exact Mass: | 3900.8636 |
IUPAC: | L-lysyl-L-cysteinyl-L-asparagyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanyl-L-asparagyl-L-phenylalanyl-L-leucyl-L-valyl-L-histidyl-L-seryl-L-seryl-L-asparagyl-L-asparagyl-L-phenylalanyl-glycyl-L-alanyl-L-isoleucyl-L-leucyl-L-seryl-L-seryl-L-threonyl-L-asparagyl-L-valyl-glycyl-L-seryl-L-asparagyl-L-threonyl-L-tyrosinamide (2->7)-disulfide |
Applications: | Amlintide, Islet Amyloid Polypeptide (IAPP) or amylin is a peptide hormone produced and stored in the beta-islet cells of the pancreas along with insulin. Amlintide forms amyloid fibrils in vitro. The deposition of fibrillar IAPP has been correlated with the pathology of type II diabetes. The helical dimerization of IAPP accelerates fibril formation and that insulin impedes fibrillation by blocking the IAPP dimerization interface. |
Storage: |
Store at -20°C for up to 2 years. |
Images: |
Amlintide Amylin Structure
Amlintide Amylin Sequence
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