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| Human PVRIG Protein (LTP11041) |
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| LTP11041 |
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| 100ug |
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$496 In stock |
| Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family.PVRIG is a cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding. |
| Recombinant Human PVRIG Protein is expressed from Expi293 with mFc (IgG1) tag at the C-terminal. It contains Thr41-Asp171. |
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| PVRIG |
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| Human |
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| Q6DKI7-1 |
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| Thr41-Asp171 |
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| The protein has a predicted MW of 39.6 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on the Tris-Bis PAGE result. |
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| Immobilized Human Nectin-2, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human PVRIG, mFc Tag with the EC50 of 0.22ug/ml determined by ELISA (QC Test). The affinity constant of 0.349 uM as determined in SPR assay (Biacore T200). See testing image for detail. |
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| C-mFc |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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