Human PD-1/PDCD1 Protein (LTP10796)

Product Name
Human PD-1/PDCD1 Protein (LTP10796)
Catalog Number
LTP10796
Quantity
100ug
Price
$406 In stock
Background
Programmed Death-1 receptor (PD-1), also known as CD279, is type I transmembrane protein belonging to the CD28 family of immune regulatory receptors.PD1 is a inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation.
Description
Recombinant Human PD-1/PDCD1 Protein is expressed from Expi293 with mFc (IgG1) tag at the C-terminal. It contains Leu25-Gln167.
Target
PD-1/PDCD1
Species
Human
Gene/Protein ID
Q15116-1
Exact Sequence
Leu25-Gln167
Molecular Weight
The protein has a predicted MW of 41.6 kDa. Due to glycosylation, the protein migrates to 64-68 kDa based on the Tris-Bis PAGE result.
Activity
Immobilized Human PD-1, mFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Human PD-L1, hFc Tag with the EC50 of 0.93ug/ml determined by ELISA (QC Test). See testing image for detail.
Tag
C-mFc
Express System
Expi293
Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization.
Stability and Storage

Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Shipping
Shipped at ambient temperature.
Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.

Image
Human PD-1/PDCD1 Protein (LTP10796)
  • 5 Units in Stock

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