Human Noggin Protein (LTP10965)

Product Name
Human Noggin Protein (LTP10965)
Catalog Number
LTP10965
Quantity
100ug
Price
$406 In stock
Background
Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer Genome Atlas human GC cohort. Targeting EGFR and its downstream pathways diminished cell proliferation which was promoted by Noggin. Noggin promotes the proliferation of GC cells by upregulating EGFR and enhancing a vicious circle formed by ??catenin, EGFR, ERK and Akt.
Description
Recombinant Human Noggin Protein is expressed from CHO without tag. It contains Gln28-Cys232.
Target
Noggin
Species
Human
Gene/Protein ID
Q13253
Exact Sequence
Gln28-Cys232
Molecular Weight
The protein has a predicted MW of 23.05 kDa. Due to glycosylation, the protein migrates to 30-36 kDa based on the Tris-Bis PAGE result.
Activity
0
Tag
No Tag
Express System
CHO
Purity
> 95% as determined by Tris-Bis PAGE
Endotoxin
Less than 1EU per ug by the LAL method.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization.
Stability and Storage

Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Shipping
Shipped at ambient temperature.
Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.

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Human Noggin Protein (LTP10965)
  • 5 Units in Stock

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