Human LAIR1/CD305 Protein (LTP10943)

Product Name
Human LAIR1/CD305 Protein (LTP10943)
Catalog Number
LTP10943
Quantity
100ug
Price
$450 In stock
Background
LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily.LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.
Description
Recombinant Human LAIR1/CD305 Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Gln22-His163.
Target
LAIR1/CD305
Species
Human
Gene/Protein ID
Q6GTX8-1
Exact Sequence
Gln22-His163
Molecular Weight
The protein has a predicted MW of 18.2 kDa. Due to glycosylation, the protein migrates to 30-36 kDa based on the Tris-Bis PAGE result.
Activity
Immobilized Human LAIR1, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-LAIR1 Antibody, hFc Tag with the EC50 of 15.3ng/ml determined by ELISA. The affinity constant of 0.082 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Tag
C-His-Avi
Express System
Expi293
Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization.
Stability and Storage

Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Shipping
Shipped at ambient temperature.
Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.

Image
Human LAIR1/CD305 Protein (LTP10943)
  • 5 Units in Stock

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