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| Human LAIR1/CD305 Protein (LTP10943) |
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| LTP10943 |
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| 100ug |
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$450 In stock |
| LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily.LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. |
| Recombinant Human LAIR1/CD305 Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Gln22-His163. |
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| LAIR1/CD305 |
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| Human |
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| Q6GTX8-1 |
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| Gln22-His163 |
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| The protein has a predicted MW of 18.2 kDa. Due to glycosylation, the protein migrates to 30-36 kDa based on the Tris-Bis PAGE result. |
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| Immobilized Human LAIR1, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-LAIR1 Antibody, hFc Tag with the EC50 of 15.3ng/ml determined by ELISA. The affinity constant of 0.082 nM as determined in SPR assay (Biacore T200). See testing image for detail. |
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| C-His-Avi |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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