Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein (LTP10718)

Product Name
Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein (LTP10718)
Catalog Number
LTP10718
Quantity
100ug
Price
$563 In stock
Background
ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.
Description
Recombinant Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Phe31-Val992(ITGAV) acidic tail&Gly22-Asn707(ITGB6) basic tail.
Target
Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer
Species
Human
Gene/Protein ID
P06756-1(ITGAV)&P18564-1(ITGB6)
Exact Sequence
Phe31-Val992(ITGAV) & Gly22-Asn707(ITGB6)
Molecular Weight
The protein has a predicted MW of 114 kDa (ITGAV)&79.1 kDa (ITGB6). Due to glycosylation, the protein migrates to 90-150 kDa based on the Tris-Bis PAGE result.
Activity
Immobilized Human ITGAV&ITGB6, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 0.10ug/ml determined by ELISA. See testing image for detail.
Tag
C-His-Avi
Express System
Expi293
Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization.
Stability and Storage

Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Shipping
Shipped at ambient temperature.
Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.

Image
Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein (LTP10718)
  • 5 Units in Stock

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