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| Human IL-1R3/IL-1 RAcP Protein (LTP10905) |
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| LTP10905 |
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| 100ug |
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$203 In stock |
| IL-1 Receptor Accessory Protein (IL-1 RAcP), also known as IL-1 R3, is a ubiquitously expressed 70-90 kDa member of the Interleukin-1 receptor family of proteins. It serves as a non-ligand-binding component of the receptors for IL-1 alpha, IL-1 beta, IL-33, and IL-36. IL-1 R3 is a coreceptor for IL1RL2 in the IL-36 signaling system. IL-1 R3 is a coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. |
| Recombinant Human IL-1R3/IL-1 RAcP Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Ser21-Glu359. |
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| IL-1R3/IL-1 RAcP |
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| Human |
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| Q9NPH3-1 |
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| Ser21-Glu359 |
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| The protein has a predicted MW of 42 kDa. Due to glycosylation, the protein migrates to 52-70 kDa based on the Tris-Bis PAGE result. |
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| Immobilized Human IL-1R3, His Tag at 0.5ug/ml (100ul/Well) on the plate. Dose response curve for Anti-IL-1R3 Antibody, hFc Tag with the EC50 of 17.4ng/ml determined by ELISA. See testing image for detail. |
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| C-His-Avi |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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