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| Human IL-17A/CTLA-8 Protein (LTP10650) |
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| LTP10650 |
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| 100ug |
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$473 In stock |
| Interleukin?17A (IL?17A), also known as CTLA?8, is a 15?20 kDa glycosylated cytokine that plays an important role in anti?microbial and chronic inflammation. The six IL?17 cytokines (IL?17A?F) are encoded by separate genes but adopt a conserved cystine knot fold.IL-17A is a ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines. |
| Recombinant Human IL-17A/CTLA-8 Protein is expressed from Expi293 with His tag at the C-terminal. It contains Gly24-Ala155. |
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| IL-17A/CTLA-8 |
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| Human |
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| Q16552-1 |
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| Gly24-Ala155 |
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| The protein has a predicted MW of 18.2 kDa. Due to glycosylation, the protein migrates to 16-30 kDa based on the Tris-Bis PAGE result. |
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| Immobilized Human IL-17A, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-IL-17A Antibody, hFc Tag with the EC50 of 0.36ug/ml determined by ELISA (QC Test). The affinity constant of 1.57nM as determined in SPR assay (Biacore T200). See testing image for detail. |
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| C-His |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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