Human IFN gamma R1/IFNGR1 Protein (LTP10587)

Product Name
Human IFN gamma R1/IFNGR1 Protein (LTP10587)
Catalog Number
LTP10587
Quantity
100ug
Price
$226 In stock
Background
IFN-gamma and one of its receptor subunits, IFNGR1, are translocated to the nucleus, together with STAT1alpha as one macromolecular complex, via the classical importin-dependent pathway.Put IFN-gamma and its receptor subunit, IFNGR1, in direct contact with the promoter region of IFN-gamma-activated genes with associated increased activity, thus suggesting a transcriptional/cotranscriptional role for IFN-gamma/IFNGR1 as well as a possible role in determining the specificity of IFN-gamma action.
Description
Recombinant Human IFN gamma R1/IFNGR1 Protein is expressed from Expi293 with hFc tag at the C-terminal. It contains Glu18-Gly245.
Target
IFN gamma R1/IFNGR1
Species
Human
Gene/Protein ID
AAH05333
Exact Sequence
Glu18-Gly245
Molecular Weight
The protein has a predicted MW of 52.4 kDa. Due to glycosylation, the protein migrates to 60-75 kDa based on the Tris-Bis PAGE result.
Activity
Immobilized Human Human IFN gamma, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Human IFN gamma R1, hFc Tag with the EC50 of 32.7ng/ml determined by ELISA. See testing image for detail.
Tag
C-hFc
Express System
Expi293
Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization.
Stability and Storage

Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Shipping
Shipped at ambient temperature.
Reconstitution

Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.

Image
Human IFN gamma R1/IFNGR1 Protein (LTP10587)
  • 5 Units in Stock

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