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| Human IFN alpha/beta R1 Protein (LTP10952) |
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| LTP10952 |
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| 100ug |
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$450 In stock |
| IFN-alpha / beta R1, also known as IFNAR1, belongs to the class II cytokine receptor family of proteins. Class II cytokine receptors form heterodimeric receptor complexes that mediate class II cytokine signals. Subunits of the different receptor complexes are shared and serve multiple functions.Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. |
| Recombinant Human IFN alpha/beta R1 Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Lys28-Lys436. |
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| IFN alpha/beta R1 |
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| Human |
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| P17181-1 |
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| Lys28-Lys436 |
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| The protein has a predicted MW of 50.2 kDa. Due to glycosylation, the protein migrates to 74-95 kDa based on the Tris-Bis PAGE result. |
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| Immobilized Human IFNAR1, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-IFNAR1 Antibody, hFc Tag with the EC50 of 0.12ug/ml determined by ELISA. The affinity constant of 0.12 uM as determined in SPR assay (Biacore T200). See testing image for detail. |
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| C-His-Avi |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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