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Human Fibrillarin GAR-Domain Peptide PGFSPRGGGFGG, sequence PGFSPRGGGFGG, is an exact fragment from the glycine/arginine-rich N-terminal domain of human fibrillarin (FBL).
Fibrillarin and the Nucleolus
Fibrillarin is a highly conserved nucleolar protein and rRNA 2'-O-methyltransferase involved in ribosomal RNA maturation. Human fibrillarin contains a distinctive N-terminal glycine/arginine-rich (GAR) domain followed by the conserved catalytic region.
The public human fibrillarin sequence begins MKPGFSPRGGGFGGRGGF..., placing PGFSPRGGGFGG directly within the native N-terminal GAR region.
GAR / RGG-Rich Motifs
Glycine-arginine-rich regions occur in many RNA-binding and nucleolar proteins. Their repetitive composition, low sequence complexity, and frequent arginine methylation make them useful systems for studying protein-RNA interactions, post-translational modification, phase behavior, and antibody recognition.
Potential Research Applications
- Fibrillarin antibody characterization
- GAR-domain binding studies
- Arginine-methylation research
- Nucleolar protein studies
- Peptide immunogen or assay development
- RNA-binding protein research
References
UniProt Consortium FBL - rRNA 2'-O-methyltransferase fibrillarin - Homo sapiens. UniProtKB P22087.
Public source / publication
Wang YC, et al. Identification and Characterization of Glycine- and Arginine-Rich Motifs in Proteins by a Novel GAR Motif Finder Program. Genes. 2023;14(2):330.
doi: 10.3390/genes14020330.
Public source / publication Related LifeTein Services
Custom Peptide Synthesis
Fluorescent Peptide Labeling
Peptide Click Chemistry and Conjugation
Peptide Carrier Protein Conjugation
Research Use Only. Not for human, diagnostic, clinical, or therapeutic use.
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