|
| Human DLL1/Delta1 Protein (LTP10289) |
|
| LTP10289 |
|
| 100ug |
|
|
$339 In stock |
| DLL1, a Notch signaling ligand, is significantly overexpressed in ER? luminal breast cancer. Intriguingly, DLL1 overexpression correlates with poor prognosis in ER? luminal breast cancer, but not in other subtypes of breast cancer. In addition, this effect is specific to DLL1, as other Notch ligands (DLL3, JAGGED1, and JAGGED2) do not influence the clinical outcome of ER? patients. DLL1-mediated Notch signaling in breast cancer is important for tumor cell proliferation, angiogenesis, and cancer stem cell function. |
| Recombinant Human DLL1/Delta1 Protein is expressed from Expi293 with His tag at the C-terminal. It contains Gln18-Gly540. |
|
| DLL1/Delta1 |
|
| Human |
|
| NP_005609 |
|
| Gln18-Gly540 |
|
| The protein has a predicted MW of 57.6 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on the Tris-Bis PAGE result. |
|
| 0 |
|
| C-His |
|
| Expi293 |
|
| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
|
| Less than 1EU per ug by the LAL method. |
|
| Lyophilized from 0.22 um filtered solution in 50mM Tris, 150mM NaCl (pH 7.5). Normally 8% trehalose is added as a protectant before lyophilization. |
|
| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
| Shipped at ambient temperature. |
|
| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
|
|  |
