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This 25‑amino‑acid amphiphilic peptide (sequence: GWTLNSAGYLLGKINLKALAALAKKIL) is a member of the Transportan family of cell‑penetrating peptides (CPPs). Marketed by LifeTein and recently featured in a peer‑reviewed publication examining nanoparticle uptake, it stands among the most potent drivers of bystander internalization activity reported to date
Bystander Nanoparticle Delivery: Demonstrated to enhance internalization of silver nanoparticles (AgNPs) in CHO cells. In head-to-head comparison, Transportan delivered significantly higher uptake (normalized MFI ≈ 12.0) than cationic CPPs like RPAR or TAT, and far exceeded hydrophobic or MAP peptides (~1× baseline)
What Makes This Sequence Special?
Biological Significance
- Exceptional Delivery Efficiency: Among the highest-performance CPPs studied, ideal for delivering cargo into mammalian cells.
- Reproducible Quality: Synthesized and quality‑controlled by LifeTein using PeptideSyn™, ensuring consistency across batches
Assay Performance
- Custom‑Ready Format: Offered with flexible modification options (e.g. FAM labeling, biotinylation, varied formats) tailored to experimental needs.
- Studying cellular uptake mechanisms for nanomaterials, including metallic and polymeric nanoparticles.
Therapeutic Discovery Platform
- Developing cargo delivery systems, such as peptides, small molecules, or nucleic acids, via peptide coupling or conjugation.
- Screening structure‑function relationships in CPP optimization, or tailoring peptide variants for improved specificity, reduced cytotoxicity, or cargo compatibility.
This Transportan‑class peptide from LifeTein is a high‑performance tool for CPP research and nanoparticle delivery studies. With proven efficacy in enhancing bystander uptake, flexible labeling options, and LifeTein’s quality guarantee, it is ideal for investigators developing next-generation intracellular delivery platforms.
References:
Nianwu Wang, Xiangxiang Hu, Hong-Bo Pang, Improving Viral-based Gene Delivery to Mammalian Cells through Simple Co-Incubation with Transportan Peptide In Vitro, Journal of Pharmaceutical Sciences, 2025, 103920,
ISSN 0022-3549, https://doi.org/10.1016/j.xphs.2025.103920.
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