Product Name | Goserelin (D-Lys6), Glp-His-Trp-Ser-Tyr-Lys-Leu-Arg-Pro-Gly-NH2, |
Product Quantity | 5.0 mg |
Catalog Number | LT12026 |
Molecular Weight | 1255.3 |
Formula | C58H83N19013 |
Sequence | pyroGlu-His-Trp-Ser-Tyr-D-Lys-Leu-Arg-Pro-AzaGly-NH2, {pGlu}; AzaGly; {D-Lys}; C term Amide, |
Purity | 95.40% |
Product Description | Luteinizing-hormone-releasing hormone (LHRH) (GnRH) is a decapeptide (pyroQHWSYKLRPG-NH2) trophic hormone that regulates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. After knock-out of GnRH-I receptor expression, GnRH-II agonist [D-Lys6]GnRH-II still activated PTP and inhibited the EGF-induced mitogenic signal transduction. This peptide has a D-amino acid Lys to increase resistance to degradation. The analogue is used as potential targeting agents in the development of chemotherapies and as possible agonists and antagonist of the LHRH receptor. |
Scientific Background | Goserelin (D-Lys6), Glp-His-Trp-Ser-Tyr-Lys-Leu-Arg-Pro-Gly-NH2, is a synthetic research peptide in the goserelin GnRH agonist peptide family. Goserelin is a synthetic gonadotropin-releasing hormone analog in which sequence modification confers prolonged GnRH-receptor agonist activity. It is used as a defined reference ligand in GnRH receptor, peptide analog, and analytical studies. Exact formulation and salt form should be distinguished from the peptide itself. |
Research Applications | - GnRH receptor research
- GnRH analog structure-activity studies
- analytical method development
- peptide identity and purity controls
|
Experimental Notes | The exact sequence, residue range, species, stereochemistry, terminal state, labels, and other modifications can materially affect activity. Match the supplied construct to the intended assay and published reference context. |
Selected References | - GnRH and synthetic analogues analytical characterization
|
