[Glu1] Fibrinopeptide B, human

[Glu1] Fibrinopeptide B, human is a synthetic research peptide in the fibrinopeptide / fibrinogen cleavage family. Fibrinopeptides A and B are released from the N-terminal regions of fibrinogen chains during thrombin-mediated conversion of fibrinogen to fibrin. Sequence-defined fibrinopeptides and modified analogs are useful in thrombin-cleavage studies, coagulation research, immunoassay development, analytical standards, and investigations of fibrin formation.

• receptor or ligand-binding assays
• competition studies
• biochemical or enzymatic assays
• analytical LC-MS/HPLC methods
• antibody controls
• cell-based experiments
• comparative structure-activity studies

For a fragment, residue-substituted analog, stereochemical variant, labeled peptide, or terminally modified form, experimental behavior should be evaluated for the exact construct rather than assumed to match the native parent peptide. Sequence-dependent solubility, aggregation, adsorption, oxidation, and stability should be considered when establishing reconstitution, storage, and assay conditions.

1. Radioimmunoassay of human fibrinopeptide B and kinetics of fibrinopeptide release
2. Structural basis for sequential cleavage of fibrinopeptides A and B by thrombin