Galanin Message Associated Peptide (1-41), amide; GMAP (1-41), a

Galanin Message Associated Peptide (1-41), amide; GMAP (1-41), a is a synthetic research peptide in the galanin family. Galanin is a 29/30-residue neuroendocrine peptide that acts through galanin receptors. Its N-terminal region is an important determinant of receptor interaction, and synthetic fragments and analogs have been used to examine receptor subtype pharmacology, peptide conformation, membrane association, and the structural requirements for galanin signaling.

• receptor-binding
• competition assays
• functional signaling assays
• enzymatic-processing or stability studies
• antibody controls
• LC-MS/HPLC method development
• comparative structure-activity experiments

For a fragment, residue-substituted analog, stereochemical variant, labeled peptide, or terminally modified form, experimental behavior should be evaluated for the exact construct rather than assumed to match the native parent peptide. Sequence-dependent solubility, aggregation, adsorption, and stability should be considered when selecting reconstitution and assay conditions.

1. NMR study of the conformation and localization of porcine galanin in phospholipid bilayers