Product Name | FSLLRY |
Product Quantity | 5 mg |
Catalog Number | L36 |
Category | Peptide |
Sequence | FSLLRY (Modifications: Tyr-6 = C-terminal amide) |
Purity | >95% |
Modifications | Amidation |
Peptide Info | FSLLRY-NH2, a protease-activated receptor 2 (PAR2) antagonist, activates mas-related G protein-coupled receptor C11 (MrgprC11) to induce scratching behaviors in mice. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch. Formal Name: L-phenylalanyl-L-seryl-L-leucyl-L-leucyl-L-arginyl-L-tyrosinamide; CAS Number: 245329-02-6; Molecular Formula: C39H60N10O8; Formula Weight: 797.0 |
Scientific Background | FSLLRY is a 6-residue synthetic peptide with the sequence Phe-Ser-Leu-Leu-Arg-Tyr. C-terminal amidation removes the terminal carboxylate charge. The sequence has a relatively high hydrophobic-residue fraction that can influence aqueous solubility and surface adsorption. These sequence-derived properties describe the reagent chemically; no specific receptor, enzyme, pathway, disease association, or biological activity is assigned without product-specific experimental evidence. |
Research Applications | - LC-MS/HPLC analytical method development
- sequence-specific assay controls
|
Experimental Notes | Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions. |
