DSPE-PEG2000-HA Tag Peptide

DSPE-PEG2000-HA Tag Peptide is based on the canonical influenza hemagglutinin epitope tag YPYDVPDYA, commonly known as the HA tag. The construct includes an N-terminal cysteine/GGGG spacer and a DSPE-PEG2000 lipid conjugation configuration.

HA Epitope Tag

The HA tag is a compact nine-amino-acid peptide derived from influenza hemagglutinin. It is widely used for detection, immunoprecipitation, affinity capture, and localization of recombinant proteins because many well-characterized anti-HA antibodies are available.

DSPE-PEG2000-HA Configuration

The N-terminal cysteine allows maleimide coupling to DSPE-PEG2000. DSPE provides a phospholipid anchor and PEG2000 provides a hydrophilic spacer, making this format useful for displaying an HA epitope on liposomes, lipid nanoparticles, micelles, or model membranes.

• Anti-HA antibody binding
• Lipid-particle surface labeling
• Immunocapture controls
• Membrane display studies

References

Thermo Fisher Scientific Overview of Epitope Tagging. Technical reference.
Public source / publication

Related LifeTein Services

Custom Peptide Synthesis
Fluorescent Peptide Labeling
Peptide Click Chemistry and Conjugation
Peptide Carrier Protein Conjugation

Research Use Only. Not for human, diagnostic, clinical, or therapeutic use.

DSPE-PEG2000-HA Tag Peptide is a 14-residue synthetic peptide with the sequence Cys-Gly-Gly-Gly-Gly-Tyr-Pro-Tyr-Asp-Val-Pro-Asp-Tyr-Ala. The sequence contains 1 cysteine residue, providing potential thiol/disulfide chemistry when the thiol is available; contains 3 aromatic residues that can contribute to hydrophobic or aromatic interactions; is Gly/Pro-rich, a composition that can influence local backbone flexibility. These sequence-derived properties describe the reagent chemically; no specific receptor, enzyme, pathway, disease association, or biological activity is assigned without product-specific experimental evidence.

• thiol-selective conjugation or immobilization studies
• LC-MS/HPLC analytical method development
• sequence-specific assay controls

Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions.