|
| Cynomolgus SOST/Sclerostin Protein (LTP10085) |
|
| LTP10085 |
|
| 100ug |
|
|
$450 In stock |
| SOST, also known as sclerostin, is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. |
| Recombinant Cynomolgus SOST/Sclerostin Protein is expressed from Expi293 with His tag at the C-terminal. It contains Gln69-Tyr258. |
|
| SOST/Sclerostin |
|
| Cynomolgus |
|
| XP_005584428.2 |
|
| Gln69-Tyr258 |
|
| The protein has a predicted MW of 22.58 kDa. Due to glycosylation, the protein migrates to 30-40 kDa based on the Tris-Bis PAGE result. |
|
| Immobilized Cynomolgus SOST, His Tag at 0.2ug/ml (100ul/Well) on the plate. Dose response curve for Anti-SOST Antibody, hFc Tag with the EC50 of 6.1ng/ml determined by ELISA. See testing image for detail. |
|
| C-His |
|
| Expi293 |
|
| > 95% as determined by Tris-Bis PAGE |
|
| Less than 1EU per ug by the LAL method. |
|
| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization. |
|
| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
| Shipped at ambient temperature. |
|
| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
|
|  |
