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| Cynomolgus IL-18 R1/CD218a Protein (LTP10031) |
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| LTP10031 |
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| 100ug |
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$473 In stock |
| Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-? production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-? production in response to IL-18 stimulation. |
| Recombinant Cynomolgus IL-18 R1/CD218a Protein is expressed from Expi293 with His tag at the C-terminal. It contains Cys22-Gly329. |
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| IL-18 R1/CD218a |
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| Cynomolgus |
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| A0A2K5V3J9 |
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| Cys22-Gly329 |
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| The protein has a predicted MW of 36.45 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on the Tris-Bis PAGE result. |
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| The affinity constant of 2.02 nM as determined in SPR assay (Biacore T200). See testing image for detail. |
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| C-His |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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