cyclo(RGDfC)

cyclo(RGDfC) is a synthetic research peptide in the cyclic RGD integrin-binding peptide family. Cyclic RGD peptides such as c(RGDfK) and c(RGDyK) are conformationally constrained ligands widely used to study RGD-recognizing integrins, especially integrin alphaVbeta3. Cyclization and the identity of the aromatic residue can strongly influence affinity and selectivity relative to linear RGD peptides.

• integrin alphaVbeta3 binding assays
• cell-adhesion and competition studies
• cyclic-versus-linear RGD comparisons
• integrin-targeting research

The exact sequence, residue range, stereochemistry, cyclization, terminal state, species, and chemical modifications can materially affect activity. The supplied construct should be matched to the intended assay and the specific literature context.

1. Ligands for mapping alphavbeta3-integrin expression in vivo
2. Evaluation of In-labeled cyclic RGD peptides