Cecropin A (1-8)-Melittin (1-18) amide

Cecropin A (1-8)-Melittin (1-18) amide is a synthetic research peptide in the cecropin antimicrobial peptide family. Cecropins are cationic amphipathic antimicrobial peptides originally characterized in insects. Cecropin A studies show close relationships among membrane binding, membrane permeabilization, and antibacterial activity. Native cecropins, terminal variants, and cecropin-derived hybrid peptides are useful for membrane-interaction, antibacterial, peptide-structure, and antimicrobial mechanism studies.

• receptor or ligand-binding assays
• competition studies
• biochemical or enzymatic assays
• analytical LC-MS/HPLC methods
• antibody controls
• cell-based experiments
• comparative structure-activity studies

For a fragment, residue-substituted analog, stereochemical variant, labeled peptide, or terminally modified form, experimental behavior should be evaluated for the exact construct rather than assumed to match the native parent peptide. Sequence-dependent solubility, aggregation, adsorption, oxidation, and stability should be considered when establishing reconstitution, storage, and assay conditions.

1. Antibacterial and antimembrane activities of cecropin A in Escherichia coli
2. Membrane binding, structure, and localization of cecropin A