Product Name | Calcineurin Autoinhibitory Fragment |
Product Quantity | 5mg |
Catalog Number | LT1176 |
Molecular Weight | 2930.38 |
Formula | C124H205N39O39S2 |
Sequence | Ile-Thr-Ser-Phe-Glu-Glu-Ala-Lys-Gly-Leu-Asp-Arg-Ile-Asn-Glu-Arg-Met-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro |
Product Description | Calcineurin Autoinhibitory Fragment is a specific calcineurin inhibitor, coded by the autoinhibitory gene for serine/threonine specific protein phosphatase, corresponds to a C-terminal domain (residues 457-482) of the calmodulin-binding domain of calcineurin. This peptide is a specific inhibitor for calcineurin (PP2BA), a Ser/Thr protein phosphatase from the PPP family and PP2B subfamily. |
Scientific Background | Calcineurin Autoinhibitory Fragment is a synthetic research peptide in the calcineurin regulatory peptide family. Calcineurin is a Ca2+/calmodulin-dependent serine/threonine phosphatase. Synthetic calcineurin substrate and autoinhibitory-region peptides are used to study phosphatase activity, substrate recognition, calmodulin-dependent regulation, and inhibition of calcineurin signaling. |
Research Applications | - calcineurin phosphatase assays
- substrate recognition studies
- autoinhibitory peptide experiments
- Ca2+/calmodulin signaling research
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Experimental Notes | The exact sequence, residue range, species, stereochemistry, terminal state, labels, and other modifications can materially affect activity. Match the supplied construct to the intended assay and published reference context. |
Selected References | - Calcineurin peptide substrate and autoinhibitory-region literature
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