Brevinin–1

Brevinin–1 is a synthetic research peptide in the brevinin amphibian antimicrobial peptide family. Brevinins are cationic host-defense peptides found in frog skin secretions. Members of the brevinin-1 family vary substantially in sequence, hydrophobicity, antimicrobial spectrum, and cytotoxicity. Synthetic brevinins are useful for examining how peptide composition and the characteristic C-terminal region influence membrane activity.

• antimicrobial activity assays
• membrane interaction studies
• hemolysis/cytotoxicity comparisons
• frog peptide structure-activity research

The exact sequence, isoform, residue substitutions, amidation, stereochemistry, labels, and other chemical modifications can change activity substantially. For receptor-activating peptides and membrane-active peptides, concentration and assay format are especially important and should be matched to the intended experimental system.

1. An atypical member of the brevinin-1 family of antimicrobial peptides
2. Brevinin-1 and bioactive peptides from Rana palustris skin