| Braftide is a 10-mer peptide TRHVNILLFM. Braftide disrupts BRAF dimers and inhibits BRAF kinase activity. Braftide causes degradation of BRAF leading to destabilized MAPK complexes. Braftide synergizes with ATP-competitive inhibitors like Dabrafenib to mitigate paradoxical MAPK activation and downregulate MAPK signaling. |
