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| Biotinylated Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein (LTP10145) |
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| LTP10145 |
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| 100ug |
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$900 In stock |
| ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. |
| Recombinant Biotinylated Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Phe31-Val992(ITGAV) acidic tail&Gly22-Asn707(ITGB6) basic tail. |
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| Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer |
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| Human |
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| P06756-1(ITGAV)&P18564-1(ITGB6) |
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| Phe31-Val992(ITGAV) & Gly22-Asn707(ITGB6) |
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| The protein has a predicted MW of 114 kDa (ITGAV)&79.1 kDa (ITGB6). Due to glycosylation, the protein migrates to 90-150 kDa based on the Tris-Bis PAGE result. |
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| Immobilized Human Latent TGF beta 1, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human ITGAV&ITGB6, His Tag with the EC50 of 1.2ug/ml determined by ELISA. See testing image for detail. |
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| C-His-Avi |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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