|
| Biotinylated Human IL-18BP Protein (LTP10573) |
|
| LTP10573 |
|
| 100ug |
|
|
$789 In stock |
| Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice. |
| Recombinant Biotinylated Human IL-18BP Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Thr31-Gly194. |
|
| IL-18BP |
|
| Human |
|
| O95998-1 |
|
| Thr31-Gly194 |
|
| The protein has a predicted MW of 20.5 kDa. Due to glycosylation, the protein migrates to 52-65 kDa based on the Tris-Bis PAGE result. |
|
| The affinity constant of 0.90 nM as determined in SPR assay (Biacore T200). See testing image for detail. |
|
| C-His-Avi |
|
| Expi293 |
|
| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
|
| Less than 1EU per ug by the LAL method. |
|
| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization. |
|
| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
| Shipped at ambient temperature. |
|
| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
|
|  |
