Biotin-LC Alpha-Synuclein (81-100) Peptide is derived from the canonical 140-amino-acid human alpha-synuclein protein encoded by SNCA. The sequence corresponds to residues 81-100 of the public UniProtKB P37840 alpha-synuclein sequence. Alpha-Synuclein Biology Alpha-synuclein is a neuronal protein associated with presynaptic vesicles and is studied extensively in synaptic biology, membrane interaction, protein aggregation, and neurodegenerative disease research. The canonical human protein contains 140 amino acids. The N-terminal region contains repeated KTKEGV-like motifs and can adopt amphipathic helices upon membrane binding. The central hydrophobic region contributes to fibril formation, while the C-terminal region is acidic, disordered, and rich in sites for protein interaction and post-translational modification. Fragment Location: Residues 81-100 This fragment overlaps the central/NAC-proximal region of alpha-synuclein, which is important in aggregation and fibril formation. Special Feature of LT8730 The LC-biotin modification provides an affinity/detection handle while adding a spacer between biotin and the peptide. Research Applications - Alpha-synuclein antibody epitope mapping
- ELISA and binding assays
- Protein-peptide interaction studies
- Aggregation-related research
- Post-translational modification studies
- Assay controls and standards
Canonical Human Alpha-Synuclein Sequence Source The complete 140-residue human sequence is publicly curated in UniProtKB entry P37840. The peptide sequence in LT8730 is a contiguous fragment of that canonical sequence, with the indicated research modification where applicable. References UniProt Consortium SNCA - Alpha-synuclein - Homo sapiens. UniProtKB P37840.
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Peptide Carrier Protein Conjugation Research Use Only. Not for human, diagnostic, clinical, or therapeutic use. | 