SPIKE_1145-1159 LDSFKEELDKYFKNH The peptide FKEELDKYFKN has been identified as a linear epitope with immunodominant properties and is linked to neutralizing activity against SARS-CoV-1. While it hasn’t yet been structurally resolved via X-ray crystallography or cryo-electron microscopy, studies show its potential to mediate immune responses similar to known SARS-CoV-1 neutralizing epitopes. For SARS-CoV-1, antibodies targeting this peptide can neutralize the virus by binding to the spike protein and blocking receptor interactions necessary for viral entry. Computational predictions suggest that this peptide could have similar neutralizing effects for SARS-CoV-2, making it a promising target for future vaccine and therapeutic designs. In vaccine research, targeting linear immunodominant epitopes like FKEELDKYFKN can stimulate robust immune responses. When used in multi-epitope vaccine constructs, such epitopes might increase vaccine efficacy by engaging with neutralizing antibodies across viral variants. This epitope's sequence similarity to other SARS-CoV-2 neutralizing sites further supports its potential as a cross-reactive target, essential for designing broad-spectrum antiviral agents | 