Biotin-Dynorphin A (1-17)

Biotin-Dynorphin A (1-17) is a synthetic research peptide in the dynorphin family. The listed sequence/design is Biotin-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln. Dynorphin peptides are endogenous opioid ligands with strong relevance to kappa-opioid-receptor research. Fragments and analogs are used to probe receptor binding, conformation, processing, and sequence determinants of opioid activity.

• receptor or binding assays
• competition experiments
• enzymatic-processing studies
• antibody or antigen controls
• analytical method development
• LC-MS/HPLC reference work
• comparative structure-activity experiments

Because this product may be a fragment, substituted analog, stereochemical variant, or terminally modified form, its activity should not be assumed to be identical to the native parent peptide. Peptide solubility, aggregation, adsorption to surfaces, and stability can vary with sequence, concentration, pH, ionic strength, and terminal modifications, so assay-specific reconstitution and storage conditions should be validated experimentally.

1. NMR structure and dynamics of dynorphin bound to human kappa opioid receptor (PMID 26372966).
2. Modification of basic residues of dynorphin A-(1-13) and kappa receptor selectivity (PMID 1360025).