Beta-Amyloid (1-40) S26C

Replacing Ser26 with cysteine provides a thiol within Aβ40 that can support covalent dimer formation under oxidizing conditions. The construct is useful for controlled studies of Aβ dimerization and aggregation.

• familial amyloid mutation studies
• Aβ aggregation and oligomerization
• Alzheimer disease research
• mutant versus wild-type comparisons

Mutation identity and Aβ C-terminal length are integral to this reagent. Compare with the sequence-matched wild-type Aβ40 or Aβ42 under identical preparation and aggregation conditions.

1. Selected mutation/amyloid study