[Arg91, Ala96] - MBP (87 - 99), human

Product Name
[Arg91,Ala96]-MBP (87-99), human
Product Description
 The immunodominant myelin basic protein (MBP) peptide comprising residues 87-99 is a self-antigen in multiple sclerosis (MS). Lys(91) and Pro(96) residues are important for encephalitogenicity. Replacement of Lys and/or Pro residues with Arg and/or Ala, respectively, results in suppression of experimental allergic encephalomyelitis (EAE). The potent linear altered peptide ligand of the immunodominant sequence MBP(87-99) may lead to the design of potent antagonist mimetics for treating MS. The altered peptide ligands (APLs) has a different topology, which could provide a possible mechanism of action for T-cell receptor (TCR) antagonism.

Reference 1: DOI: 10.1021/jm0102147;

Reference 2: DOI: 10.1016/j.jmgm.2007.02.004

Product Quantity
5mg
Catalog Number
LT0463
Molecular Weight
1557.83
Formula
C72H112N22O17
Sequence
Val-His-Phe-Phe-Arg-Asn-Ile-Val-Thr-Ala-Arg-Thr-Pro, VHFFRNIVTARTP
[Arg91,Ala96]-MBP (87-99), human
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