Product Name | Apamin, Bee Venom - CAS 24345-16-2 |
Product Quantity | 3mg |
Catalog Number | 5595 |
Sequence | CNCKAPETALCARRCQQH, H-Cys¹-Asn-Cys³-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys¹¹-Ala-Arg-Arg-Cys15-Gln-Gln-His-NH (disulfide bonds: 1 - 11; 3 - 15); Formula: C79H131N31O24S4 |
Purity | >95% |
Modifications | C-Terminal: Amidation, Disulfide Bridge: 1-11, 3-15 |
Name | Apamin CNCKAPETALCARRCQQH - NH2 (Disulfide bridge: 1 - 11, 3 - 15) |
Product Description | An 18-amino acid peptide from bee venom, a selective blocker of calcium activated potassium channels.Polypeptide neurotoxin known to pass through the blood-brain barrier. Blocks the AHP-type Ca2+-activated K+ channel; does not block the TEA and voltage-sensitive Ca2+-activated K+ channel. Reported to induce neurodegeneration of Purkinje cells in rat brain. Known to induce the secretion of prolactin in a dose-dependent manner. |
Scientific Background | Apamin, Bee Venom - CAS 24345-16-2 is a 18-residue synthetic peptide with the sequence Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His. The sequence contains 4 cysteine residues, allowing thiol/disulfide chemistry when available; contains 1 Lys and 2 Arg residues, contributing cationic character. These sequence-derived properties describe the reagent chemically; no specific biological activity is assigned without product-specific experimental evidence. |
Research Applications | - thiol-selective conjugation or immobilization studies
- LC-MS/HPLC analytical method development
- sequence-specific assay controls
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Experimental Notes | Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended conditions. |
